Neurobiology of Disease Caspase-11 Mediates Inflammatory Dopaminergic Cell Death in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Mouse Model of Parkinson’s Disease
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چکیده
Tsuyoshi Furuya,1 Hideki Hayakawa,1 Masanori Yamada,2 Kenji Yoshimi,2 Shin Hisahara,3 Masayuki Miura,4,5 Yoshikuni Mizuno,1,2 and Hideki Mochizuki1,2 1Department of Neurology and 2Research Institute for Disease of Old Ages, Juntendo University School of Medicine, Bunkyo-ku, Tokyo 113-8421, Japan, 3Department of Neurology, Department of Pharmacology Graduate School of Medicine, Program of Signal Transduction Medicine, Division of Brain–Neural Sciences, Neuro-molecular Pharmacology School of Medicine, Sapporo Medical University, Sapporo 060-8556, Japan, 4Laboratory for Cell Recovery Mechanisms, RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan, and 5Department of Genetics, Graduate School of Pharmaceutical Sciences, University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan
منابع مشابه
The effects of aqueous cinnamon bark extract and cinnamaldehyde on neurons of substantia nigra and behavioral impairment in a mouse model of Parkinson’s disease
Background and Objective: Parkinson's disease (PD) is characterized by a progressive loss of dopaminergic neurons in substantia nigra. In recent years, there have been interests in the role of the free radical damage in PD. Cinnamon and its derivative, cinnamaldehyde acts as powerful antioxidant and anti-inflammatory agents. This research focused on the effects of cinnamon extract and cinnamald...
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تاریخ انتشار 2004